Endocrine Abstracts

Prader–Willi syndrome is a complex genetic disorder. The characteristics of hypotonia put children at increased risk of respiratory problems during childhood. These range from an increased propensity to respiratory infection to problems during sleep of central and obstructive sleep apnoea. Obesity a common finding in children with Prader–Willi syndrome has the tendency to exacerbate these increased risks. There are often concerns around the use of GH in children with...

Background: The role of weight loss in the management and prevention of type 2 diabetes has grabbed the attention of the media and the NHS, supported by the extremely positive DROPLET trial results. Very Low Calorie Diets (VLCDs) are being recognised as a valuable treatment option for type 2 diabetes, with a qualified healthcare professional closely involved. The NHS has announced plans for a pilot project in 2019 to establish the feasibility of this approach within the NHS st...

Nuclear hormone receptors (NHRs) are a large family of ligand-activated transcription factors that regulate programs of cellular growth, differentiation and homeostasis. The structurally conserved ligand binding domains (LBDs) of NHRs bind to hydrophobic small molecules including steroid hormones, fat soluble vitamins and bile acids, thereby interpreting small molecule cues to affect transcriptional readouts.The temporal correspondence between metabolic ...

Iron, an essential trace element for almost all organisms, has a structural or functional role in a number of proteins and enzymes. Total body iron amounts to ~35 and 45 mg/kg of body weight in healthy adult women and men, respectively. This iron is highly conserved and daily iron losses, normally only 0.5 to 2 mg via non-specific processes, are compensated for by absorption of an equivalent amount of iron from the diet. The precise regulation of cellular iron uptake and stora...

Ronald M Evans, The Salk Institute for Biological Studies, LaJolla, California, USA Abstracthttp://www.endocrine-abstracts.org/ea/0031/ea0031pl1biog.htm...

Dr. Ronald M Evans is known for his discoveries and characterization of nuclear hormone receptors, the establishment of the nuclear receptor super family and the elucidation of their universal mechanism of action, this revealed how receptor activation by lipophilic hormones and drugs are transformed into physiology and the treatment of disease.Dr R M Evans obtained his BA and PhD from the University of California, Los Angeles, School of Medicine in 1970 ...

Diabetic retinopathy remains the leading cause of blindness in the developed world resulting in significant morbidity for the diabetes population. As yet the specific pathogenesis remains elusive. Endogenous growth hormone (GH) is implicated in the development of retinal new vessels that characterize proliferative retinopathy. Both endogenous GH and its active protein, Insulin like growth factor-1 (IGF-1) have been found to be at high levels in diabetes, especially in patients...

Background: The incidence of gestational diabetes appears to be rising, likely related to the increasing prevalence of overweight/obesity in the general population, and the trend of increasing maternal age. However, it must be remembered that some women newly diagnosed with diabetes in pregnancy have latent type 1 diabetes; GAD (glutamic acid decarboxylase) antibody measurement may be useful in cases with atypical features. We present two such cases.Case...

A 40-year-old woman was admitted for investigation of severe fatigue, abdominal pain, anorexia and myalgia over the preceding year. Past medical history included vitiligo, coeliac disease and depression. Initial investigations revealed hyperkalaemia, normocytic anaemia and hypercalcaemia with an inappropriately normal parathyroid hormone level. Low TSH with normal free T4 and T3 (0.02 milliunits per litre, 17.1 picomoles per litre and 6.3 picomoles per litre respectively) were...

Abstract for Society for Endocrinology Conference 2003Category: Clinical case report (Young Endocrinologist)AbstractTitle: A CASE OF HYPERTHYROIDISM PRESENTING AS HAEMATOLOGICAL MALIGNANCYAuthors: K.M. Evans, D.E. Flanagan; Dept. of Endocrinology and Diabetes, Derriford Hospital, Plymouth, PL6 8DHA 30 yr old man was referred to the Haematology department with axil...